Suzuki Kenta, Ohkoshi Shogo, Yano Masahiko, Ichida Takafumi, Takimoto Mitsuhiro, Naitoh Akira, Mori Shigeki, Hata Kojiro, Igarashi Kentaro, Hara Hidenori, Ohta Hironobu, Soga Kenji, Watanabe Toshiaki, Kamimura Tomoteru, Aoyagi Yutaka
Department of the Internal Medicine III, School of Medicine, Niigata University, 1-754 Asahimachi-Dori, Niigata City, 951-8122.
Liver Int. 2003 Jun;23(3):143-7. doi: 10.1034/j.1600-0676.2003.00822.x.
Clinical background and incidence of hepatocellular carcinoma (HCC) of patients with chronic hepatitis C who obtained biochemical remission without eradication of virus (biochemical response) after interferon (IFN) treatment was retrospectively analyzed for 755 patients. Annual incidence of HCC was significantly lower in the patients with biochemical response and sustained response than that of the patients that did not show these responses. Logistic regression analysis showed that only the normalization of alanine aminotransferase (ALT) value at the end of IFN treatment was a significant factor for biochemical response. Annual incidence of HCC was significantly lower in the patients who obtained normalization of ALT values at the end of treatment than those who did not. Patients who were younger, who had a lower level of activity and fibrosis indices in histology, higher platelet count, and who were given more higher total dose of IFN were more likely to attain normalization of ALT levels at the end of treatment, and this was related to biochemical response. Low incidence of HCC in patients who obtained normalization of ALT values at the end of treatment was likely because they were in the earlier stage of chronic hepatitis. Active treatment of chronic hepatitis C with interferon in the early phase of the disease may bring about a biochemical response in some patients, even if sustained virological response is not obtained.
