Hastings Michael H
Division of Neurobiology, MRC Laboratory of Molecular Biology, Hills Road, CB2 2QH, Cambridge, UK.
Curr Biol. 2003 Sep 2;13(17):R681-2. doi: 10.1016/s0960-9822(03)00608-0.
Circadian clocks are auto-regulatory loops in which 'clock' gene products feedback to regulate their own expression. This explains how they keep oscillating, but how do they first get going? It appears that the transcription factor dClock not only drives the oscillation within the fruit fly's clock, but also plays a pivotal role in pre-assembling the clockwork.
生物钟是一种自动调节循环,其中“时钟”基因产物通过反馈来调节自身的表达。这解释了它们如何持续振荡,但它们最初是如何启动的呢?似乎转录因子dClock不仅驱动果蝇生物钟内的振荡,还在预组装生物钟机制中起关键作用。