Murthy Prad, Riesberg Michael V, Hart Steve, Bustillo Andres, Duque Carlos S, Said Sheriff, Civantos Francisco J
Department of Otolaryngology-Head and Neck Surgery, Univeristy of MIami School of Medicine, Miami, FL 33136, USA.
Otolaryngol Head Neck Surg. 2003 Sep;129(3):176-82. doi: 10.1016/S0194-5998(03)00603-X.
We sought to determine the thromboprophylactic effects of low-molecular-weight heparin (LMWH) and pentoxifylline.
Randomized blinded study. Materials and methods Sixty Sprague-Dawley rats were assigned to 1 of 4 treatment groups: (1) control group (n = 15), (2) pentoxifylline group (n = 15), (3) LMWH group (n = 15), and (4) combined therapy group (n = 15). A groin/abdominal free flap was elevated in each, with division of the artery and microvascular repair The animals received therapy for 4 days preoperatively and 6 days postoperatively. Flaps were monitored visually, and on the seventh postoperative day, the flap was elevated, and the microvascular anastomosis was assessed for patency.
There was a statistically significant improvement in arterial patency in both pentoxifylline and LMWH groups compared with controls (P < 0.01) but no significant improvement with combined therapy (P > 0.05).
In this animal model, LMWH and pentoxifylline have significant thrombroprophylactic effects when used individually but not in combination.
