Ge Chang-jiang, Hu Shen-jiang, Wu Yao-sen, Chen Nai-yun
First Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou 310003, China.
J Zhejiang Univ Sci. 2003 Sep-Oct;4(5):612-5. doi: 10.1631/jzus.2003.0612.
To investigate the structural changes of aorta, and evaluate the effects of atorvastatin on the remodeling of thoracic aorta in spontaneously hypertensive rats (SHR).
Twelve eight-week-old SHR were randomized into atorvastatin treated group (ATV group, n=6) and distilled water group (DW group, n=6); Wistar-Kyoto rats (WKY) were used as normal controls. Atorvastatin was administered to ATV group for 10 weeks by gavage in mixture with distilled water (1 ml); the latter two groups were given the same amount of distilled water by gavage for 10 weeks. Systolic blood pressure of caudal artery was examined before and after treatment, and serum concentrations of total cholesterol, triglycerides and HDL-C were measured. Wall thickness, media thickness, medial cross-sectional area and lumen diameter of thoracic aorta were assessed with computed video processing.
Systolic blood pressure in ATV group was markedly lower than that in DW group (P<0.01). Compared with DW group and WKY group, serum concentrations of total cholesterol, triglycerides and HDL-C in ATV group were significantly lower (P<0.01,P<0.05). Wall thickness, media thickness, and medial cross-sectional area to lumen ratio in DW group were significantly higher than those in WKY group and ATV group (P<0.01,P<0.05), but no such difference was found between WKY group and ATV group (P>0.05).
Vascular structural changes of aorta are due to the alteration of the vessel wall in early stage of SHR. Atorvastatin can markedly improve vascular remodeling.
研究主动脉的结构变化，评估阿托伐他汀对自发性高血压大鼠（SHR）胸主动脉重塑的影响。
将12只8周龄的SHR随机分为阿托伐他汀治疗组（ATV组，n = 6）和蒸馏水组（DW组，n = 6）；以Wistar - Kyoto大鼠（WKY）作为正常对照。ATV组大鼠用蒸馏水（1 ml）混合阿托伐他汀灌胃给药10周；后两组用等量蒸馏水灌胃10周。治疗前后检测尾动脉收缩压，并测定血清总胆固醇、甘油三酯和高密度脂蛋白胆固醇（HDL - C）浓度。用计算机视频处理评估胸主动脉的壁厚、中膜厚度、中膜横截面积和管腔直径。
ATV组收缩压明显低于DW组（P < 0.01）。与DW组和WKY组相比，ATV组血清总胆固醇、甘油三酯和HDL - C浓度显著降低（P < 0.01，P < 0.05）。DW组的壁厚、中膜厚度以及中膜横截面积与管腔比值显著高于WKY组和ATV组（P < 0.01，P < 0.05），但WKY组和ATV组之间未发现此类差异（P > 0.05）。
SHR早期主动脉血管结构变化是由于血管壁改变所致。阿托伐他汀可显著改善血管重塑。
