肌肉的解剖位置会影响营养不良对肌纤维数量的影响吗？
Does the anatomical location of a muscle affect the influence of undernutrition on muscle fibre number?
作者信息
Dwyer C M, Stickland N C
机构信息
Department of Veterinary Basic Sciences, Royal Veterinary College, London, UK.
出版信息
J Anat. 1992 Oct;181 ( Pt 2)(Pt 2):373-6.
Nutritional restriction during muscle fibre number development invariably has a more detrimental effect on the biceps brachii than on the soleus. The difference may be due to the relative proportions of fibre types in the muscles or the anatomical location of the muscles. To distinguish between the effects of location and fibre type the biceps (fast, cranial and proximal), soleus (slow, caudal and distal), and extensor digitorum longus (EDL) (fast, caudal and distal) were examined from control and undernourished guinea pig neonates. A 40% reduction in maternal intake resulted in a reduction in neonate body and muscle weights (P < 0.005), biceps (P < 0.05) and EDL fibre numbers (P < 0.005), but did not affect soleus fibre number. At birth the ratio of fast fibres to slow was 7.5 for the biceps, 7.0 for the EDL, and 1.5 for the soleus. The effect of undernutrition on muscle fibre number therefore seems to be a function of the fibre types in that muscle.
在肌纤维数量发育期间进行营养限制，对肱二头肌的损害总是比对比目鱼肌更严重。这种差异可能是由于肌肉中纤维类型的相对比例或肌肉的解剖位置所致。为了区分位置和纤维类型的影响，对来自对照和营养不良的豚鼠新生儿的肱二头肌（快肌，位于颅侧和近端）、比目鱼肌（慢肌，位于尾侧和远端）和趾长伸肌（EDL，快肌，位于尾侧和远端）进行了检查。母体摄入量减少40%导致新生儿体重和肌肉重量降低（P < 0.005），肱二头肌（P < 0.05）和EDL纤维数量降低（P < 0.005），但对比目鱼肌纤维数量没有影响。出生时，肱二头肌的快肌与慢肌比例为7.5，EDL为7.0，比目鱼肌为1.5。因此，营养不良对肌纤维数量的影响似乎是该肌肉中纤维类型的一个函数。
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