Li Sha, Hou Xin-pu
Department of Physical Pharmacy, School of Pharmacy, Peking University, Beijing 100083, China.
Yao Xue Xue Bao. 2003 May;38(5):380-3.
To investigate the formation mechanism, macromolecular drug loading capacity and release property of alginate-chitosan microcapsules (ACM).
ACM was prepared by emulsification-gelation method and its formation mechanism was studied by DSC analysis. Using bovine serum albumin (BSA) as model drug, the drug loading and release properties of the microcapsules on macromolecular drug were investigated.
The results of DSC analysis showed that there is electrostatic interaction between materials encapsulated in the microcapsule. With the increase of BSA microcapsule ratio, the BSA loading percentage rose from 9.20% to 35.08%; and with the ascent of chitosan (CTS) concentration, the BSA loading percentage increased from 30.29% to 38.12%. The BSA microcapsules whowed a two-phase release in both 0.1 mol.L-1 HCl and phosphate buffer saline (pH 7.4). With the increase of CTS concentration, the BSA release more and more slowly in 0.1 mol.L-1 HCl.
Spheric and well-dispersed alginate-chitosan microcapsules were prepared. The microcapsule showed good loading capacity to BSA as well as sustained release to a certain degree.
研究海藻酸钠-壳聚糖微胶囊（ACM）的形成机制、大分子药物载药量及释放特性。
采用乳化-凝胶法制备ACM，并通过差示扫描量热法（DSC）分析其形成机制。以牛血清白蛋白（BSA）为模型药物，研究微胶囊对大分子药物的载药和释放性能。
DSC分析结果表明，微胶囊内包封的材料之间存在静电相互作用。随着BSA与微胶囊比例的增加，BSA载药率从9.20%升至35.08%；随着壳聚糖（CTS）浓度的升高，BSA载药率从30.29%增至38.12%。BSA微胶囊在0.1 mol·L-1盐酸和磷酸盐缓冲液（pH 7.4）中均呈现两相释放。随着CTS浓度的增加，BSA在0.1 mol·L-1盐酸中的释放越来越慢。
制备出了球形且分散良好的海藻酸钠-壳聚糖微胶囊。该微胶囊对BSA显示出良好的载药能力以及一定程度的缓释性能。
