Chen H, Cao S, Zeng X, Meng L, Zao D, Ni J
Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, National Electrochemistry and the Analysis Center of Spectroscopy Research, 130022 Changchun.
Guang Pu Xue Yu Guang Pu Fen Xi. 2000 Jun;20(3):339-42.
Inductively coupled plasma mass spectrometry (ICP-MS), highly sensitive inorgnic analytic technique, fits to determine ultra-trace rare-earth elements in human plasma. Under the optimized conditions detection limits for 15 rare-earth elements are in the range of 0.7 (for Eu)-5.4 (for Gd) ng.L-1. Indium as an internal standard element is used to compensate for matrix suppression effect and sensitivity drift. Three kinds of preparation methods, diluted with 1% HNO3, digested with HNO3-H2O2 and with HNO3-HClO4, are checked and compared, and the former is the simplest way to be measured. The samples diluted with 1% HNO3, stored in 4 degrees C, are very steady for 16 days. With the method, 11 healthy plasma samples in Changchun area of China are analysed.
电感耦合等离子体质谱法（ICP-MS）是一种高灵敏度的无机分析技术，适用于测定人体血浆中的超痕量稀土元素。在优化条件下，15种稀土元素的检测限在0.7（铕）-5.4（钆）ng.L-1范围内。铟作为内标元素用于补偿基体抑制效应和灵敏度漂移。对用1%硝酸稀释、用硝酸-过氧化氢消解和用硝酸-高氯酸消解这三种制备方法进行了检验和比较，前者是最简单的测量方法。用1%硝酸稀释并保存在4℃的样品在16天内非常稳定。采用该方法对中国长春地区的11份健康血浆样本进行了分析。
