[表面活性剂增敏动力学分光光度法测定痕量铂]

[Surfacant sensitizing kinetic spectrophotometric determination of trace platinum].

作者信息

Li J, Wang X

机构信息

Department of Applied Chemistry, Guilin Institue of Technology, 541004 Guilin.

出版信息

Guang Pu Xue Yu Guang Pu Fen Xi. 2000 Jun;20(3):443-5.

PMID:12958985

Abstract

A new kinetic spectrophotometric method for the determination of trace amount of platinum sensitizing by surfacant of emolsifier OP was proposed. It is based on the inhibition effect of platinum (IV) on the oxidizing decoloration of acid fuchsin by potassium bromate in 0.1 mol.L-1 sulphuric acid medium. The linear range for the determination of platinum is 0-2.2 micrograms.L-1. The detection limit is 0.06 microgram.L-1. Several parameter of the kinetic reaction were determined. The method is sensitive, selective and simple. It has been applied to the determination of trace platinum in chemotherapeutic drug cisplatin and serum from patients with satisfactory results.

摘要

提出了一种新的动力学分光光度法，用于测定由乳化剂OP表面活性剂增敏的痕量铂。该方法基于在0.1mol·L⁻¹硫酸介质中，铂（IV）对溴酸钾氧化酸性品红褪色的抑制作用。测定铂的线性范围为0 - 2.2微克·L⁻¹。检测限为0.06微克·L⁻¹。确定了动力学反应的几个参数。该方法灵敏、选择性好且操作简单。已应用于化疗药物顺铂和患者血清中痕量铂的测定，结果令人满意。