Petersson Karin, Hulthén-Varli Ingela
Kvinnokliniken, Huddinge Universitetssjukhus, Stockholm.
Lakartidningen. 2003 Aug 7;100(32-33):2512-6.
The incidence of intrauterine fetal death (from the 28th gestational week) is reported to be 3.6/1000 births in Sweden. Continuous improvements in perinatal care have resulted in a dramatic decrease in early neonatal mortality during the last few decades, but no comparable reduction of antenatal mortality has been observed. A better knowledge of the etiology of stillbirth is imperative to achieve a further decrease in the perinatal mortality rate. Advanced maternal age, smoking during pregnancy, maternal overweight/obesity and low socioeconomic class has been demonstrated to increase the risk for stillbirth. Several studies have been published concerning specific causes of intrauterine fetal death. Abruption of the placenta, some infectious disorders, fetal chromosomal aberration/malformation and maternal disease such as diabetes are some of the conditions that are associated to stillbirth. In order to arrive at a potential cause, a number of investigations have been recommended in the diagnostic evaluation of IUFD.
据报道,瑞典的宫内死胎(自孕28周起)发生率为每1000例分娩中有3.6例。在过去几十年中,围产期护理的持续改善已使早期新生儿死亡率大幅下降,但产前死亡率并未出现类似程度的降低。要进一步降低围产期死亡率,必须更好地了解死产的病因。高龄产妇、孕期吸烟、孕妇超重/肥胖以及社会经济地位低下已被证明会增加死产风险。关于宫内死胎的具体原因,已有多项研究发表。胎盘早剥、一些感染性疾病、胎儿染色体畸变/畸形以及糖尿病等母体疾病是与死产相关的一些情况。为了找出潜在病因,在诊断评估胎儿宫内死亡时建议进行多项检查。