Baker Vicki V
Karmanos Cancer Institute, Wayne State University, 3990 John R. Hudson Building, Suite 4924, Detroit, MI 48201, USA.
Hematol Oncol Clin North Am. 2003 Aug;17(4):977-88. doi: 10.1016/s0889-8588(03)00057-1.
There are no comparative prospective trials to support dogmatic statements concerning the sequence and duration of therapy in the salvage setting. Although the literature offers many examples of chemotherapy studies conducted in the salvage setting, these studies typically involve relatively small numbers of younger patients whose disease shows good performance. The extrapolation of these observations to the practice setting, compounded by the clinical and molecular heterogeneity of epithelial ovarian cancer, further exacerbates the difficulties encountered in individual treatment recommendations.
在挽救治疗中，没有比较性前瞻性试验来支持关于治疗顺序和持续时间的教条式陈述。尽管文献中有许多在挽救治疗中进行的化疗研究实例，但这些研究通常涉及相对较少数量的年轻患者，他们的疾病表现良好。将这些观察结果外推至实际临床，再加上上皮性卵巢癌的临床和分子异质性，进一步加剧了个体化治疗建议中遇到的困难。
