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[咪唑类治疗药物的稳定性研究。十二、盐酸酚妥拉明溶液的定性和定量稳定性评估]

[Investigations on the stability of therapeutic drugs derived from imidazole. XII. Qualitative and quantitative stability evaluation of phentolamine hydrochloride solutions].

作者信息

Grabowska I, Rajzer D, Kraczkowska A, Kremska B

机构信息

Katedra i Zakład Chemii Farmaceutycznej Wydziału Farmaceutycznego Akademii Medycznej w Gdańsku, Al. K.Marksa 107, 80-416 Gdańsk.

出版信息

Acta Pol Pharm. 1990;47(3-4):29-35.

PMID:12959239
Abstract

Hydrolysis of phentolamine hydrochloride in aqueous solutions, and at pH 1.0 and pH 8.0 was studied by means of thin-layer chromatography. A spectrophotometric method for quantitative assessment of phentolamine hydrochloride hydrolysis has been elaborated, and thermodynamic parameters of this reaction were determined.

摘要

采用薄层色谱法研究了盐酸酚妥拉明在水溶液中以及pH值为1.0和8.0条件下的水解情况。已建立了一种用于定量评估盐酸酚妥拉明水解的分光光度法，并测定了该反应的热力学参数。

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