Bartelink M L, Wollersheim H, van de Lisdonk E, Thien T
Department of Medicine, University Hospital Nijmegen, The Netherlands.
Int Angiol. 1992 Oct-Dec;11(4):309-15.
Recent studies with standardized laboratory measurements of skin blood flow suggest an influence of female sex hormones on vasospasm. Therefore we evaluated the influence of sex hormonal status on the subjective complaints of Raynaud's phenomenon and furthermore the combined presence of Raynaud's phenomenon and migraine. A detailed questionnaire was filled in by 130 primary Raynaud patients (31 males, 99 females), while 27 females, with regular menstrual cycles without the use of oral contraceptives, kept a diary with daily registration (during three months) of frequency, severity and duration of the vasospastic attacks. Complaints improved during pregnancy in 6 out of 23 females. No influence of the menopause or the use of oral contraceptives was found. An exacerbation in some phases of the menstrual cycle was present in 15 out of 80 females. The diaries, however, did not show such influence of menstrual cycle phase. Migraine was present in 21% of the Raynaud patients. In contrast to most reports in the literature and contrary to the results of laboratory research, this study shows that most females do not experience an important subjective influence of sex hormonal status on vasospastic attacks.
近期关于皮肤血流标准化实验室测量的研究表明，女性性激素对血管痉挛有影响。因此，我们评估了性激素状态对雷诺现象主观症状的影响，以及雷诺现象与偏头痛同时存在的情况。130例原发性雷诺病患者（31例男性，99例女性）填写了一份详细问卷，同时，27例月经周期规律且未使用口服避孕药的女性记录了日记（为期三个月），每日记录血管痉挛发作的频率、严重程度和持续时间。23名女性中有6名在孕期症状改善。未发现绝经或使用口服避孕药有影响。80名女性中有15名在月经周期的某些阶段病情加重。然而，日记并未显示月经周期阶段有此类影响。21%的雷诺病患者患有偏头痛。与文献中的大多数报道以及实验室研究结果相反，本研究表明，大多数女性并未感受到性激素状态对血管痉挛发作有重要的主观影响。
