热响应和pH响应性可生物降解的聚（α-N-取代的γ-谷氨酰胺）
Thermo- and pH-responsive biodegradable poly(alpha-N-substituted gamma-glutamine)s.
作者信息
Tachibana Yoichi, Kurisawa Motoichi, Uyama Hiroshi, Kobayashi Shiro
机构信息
Department of Materials Chemistry, Graduate School of Engineering, Kyoto University, Kyoto 615-8510, Japan.
出版信息
Biomacromolecules. 2003 Sep-Oct;4(5):1132-4. doi: 10.1021/bm034123y.
New double stimuli-responsive poly(alpha-N-substituted gamma-glutamine) has been developed, which was synthesized by the reaction of poly(gamma-glutamic acid) with amino alcohols. Appropriate combinations of the amino alcohols provided the biodegradable poly(amino acid) exhibiting a sharp lower critical solution temperature (LCST) in water. Furthermore, the phase transition temperature was highly sensitive to pH changes.
新型双刺激响应性聚（α-N-取代γ-谷氨酰胺）已被开发出来，它是通过聚（γ-谷氨酸）与氨基醇反应合成的。氨基醇的适当组合提供了一种在水中表现出急剧的低临界溶液温度（LCST）的可生物降解聚（氨基酸）。此外，相变温度对pH变化高度敏感。
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