Dhont Marc
Department of Obstetrics and Gynecology, Ghent University Hospital, De Pintelaan 185, B-9000 Ghent, Belgium.
Curr Womens Health Rep. 2003 Oct;3(5):361-6.
Recurrent miscarriage is defined as the occurrence of three consecutive pregnancy losses during the first trimester. Although it affects only 1% of all couples, it is a most frustrating experience for the patient as well as for the clinician. Frustrating for the couple because they rarely obtain clear-cut reasons for the repeated failure to sustain a pregnancy, nor the prospect of a fail-safe treatment; frustrating for the clinician, too, because it is extremely difficult to disentangle the causes of sporadic and unavoidable miscarriage--most of which have a genetic background--from those of recurrent miscarriage. In the latter case, an underlying defect can potentially be detected and, ideally, should be amenable to treatment. Unfortunately, however, this is rather exceptional. In this paper, literature on genetic, anatomic, endocrine, metabolic, and autoimmune aspects of recurrent miscarriage are reviewed, and a survey of meaningful investigations and treatment is provided.
复发性流产的定义是在孕早期连续发生三次妊娠丢失。尽管它仅影响所有夫妇中的1%，但对患者和临床医生来说都是极其令人沮丧的经历。对夫妇来说令人沮丧，是因为他们很少能得到反复妊娠失败的确切原因，也没有可靠的治疗前景；对临床医生来说也令人沮丧，因为很难将偶发性和不可避免的流产（其中大多数有遗传背景）的原因与复发性流产的原因区分开来。在后一种情况下，潜在的潜在缺陷有可能被检测到，理想情况下，应该可以进行治疗。然而，不幸的是，这种情况相当罕见。本文综述了复发性流产在遗传、解剖、内分泌、代谢和自身免疫方面的文献，并提供了有意义的检查和治疗概述。
