Yang C C, Wu C C, Jong S B
Department of Nuclear Medicine, Kaohsiung Medical College, Taiwan, Republic of China.
Gaoxiong Yi Xue Ke Xue Za Zhi. 1992 Nov;8(11):605-17.
To evaluate the efficacy of stress Tc-99m MIBI myocardial perfusion imaging using intravenous dipyridamole in detecting coronary artery disease (CAD) and to determine if chest pain symptom is a proper index for detection of myocardial ischemia in post-infarction patients, we observed 73 cases (65 men, 8 women, 38-79 years old) between Sept. 1990 and May 1992. All patients were suffered from old myocardial infarction (MI) evidenced by history and ECG and were divided into two groups: group I involving 41 patients with post-infarction chest pain symptom and group II including 32 patients without post-infarction chest pain symptom. Among them, 19 (group IA) of group I and 11 (group IIA) of group II received coronary arteriography (CAG) for comparison. Of the 41 group I post-infarction chest pain patients, 17 suffered from old anterior or antero-septal wall (AW) MI, 21 from old inferior wall (IW) MI, 1 from old lateral wall (LW) MI and 2 from combined old AW and IW (AIW) MI by ECG. All 17 patients with AWMI suffered from AW perfusion defect (7 were MI, 10 were MI with ischemia) but 7 of them from multivessel disease (MVD) by Tc-99m MIBI. All 21 patients with IWMI suffered from IW perfusion defect (9 were MI, 12 were MI with ischemia) but 13 of them from MVD by Tc-99m MIBI. Of the patient with LWMI and 2 patients with AIWMI suffered from MVD by Tc-99m MIBI. Of the 32 group II post-infarction patients without chest pain symptom, 12 suffered from old AWMI, 14 from old IWMI, 2 from old LWMI, 3 from AIWMI and 1 from ALWMI by ECG. Of the 12 patients with AWMI, 11 suffered from AW perfusion defect (6 were MI, 5 were MI with ischemia) but 1 of them from MVD by TC-99m MIBI. All 14 patients with IWMI suffered from IW perfusion defect (12 were MI, 2 were MI with ischemia) but 4 of them from MVD by Tc-99m MIBI. Of the 2 patients with LWMI suffered from LW infarction by Tc-99m MIBI. Of the 3 patients with AIWMI and 1 with ALWMI suffered from MVD by Tc-99m MIBI. Of the 11 patients in group IA and 5 patients in group IIA with AWMI, CAG revealed the incidence of infarct-related recanalization of LAD was 9/11(82%) and 4/5(80%) respectively and the respective incidence of MVD was 6/11(55%) and 0/5(0%).(ABSTRACT TRUNCATED AT 400 WORDS)
为评估静脉注射双嘧达莫负荷锝-99m甲氧基异丁基异腈(Tc-99m MIBI)心肌灌注显像检测冠心病(CAD)的疗效,并确定胸痛症状是否为心肌梗死后患者心肌缺血检测的合适指标,我们于1990年9月至1992年5月观察了73例患者(65例男性,8例女性,年龄38 - 79岁)。所有患者均有陈旧性心肌梗死(MI)病史及心电图证据,并分为两组:I组41例有心肌梗死后胸痛症状;II组32例无心肌梗死后胸痛症状。其中,I组19例(IA组)和II组11例(IIA组)接受了冠状动脉造影(CAG)以作比较。I组41例心肌梗死后胸痛患者中,心电图显示17例为陈旧性前壁或前间壁心肌梗死(AWMI),21例为陈旧性下壁心肌梗死(IWMI),1例为陈旧性侧壁心肌梗死(LWMI),2例为陈旧性前壁和下壁合并心肌梗死(AIWMI)。17例AWMI患者均有前壁灌注缺损(7例为心肌梗死,10例为心肌梗死伴缺血),但其中7例为多支血管病变(MVD),通过Tc-99m MIBI检测得出。21例IWMI患者均有下壁灌注缺损(9例为心肌梗死,12例为心肌梗死伴缺血),但其中13例为MVD,通过Tc-99m MIBI检测得出。LWMI患者及2例AIWMI患者通过Tc-99m MIBI检测显示为MVD。II组32例无胸痛症状的心肌梗死后患者中,心电图显示12例为陈旧性AWMI,14例为陈旧性IWMI,2例为陈旧性LWMI, 3例为AIWMI,1例为陈旧性前侧壁心肌梗死(ALWMI)。12例AWMI患者中,11例有前壁灌注缺损(6例为心肌梗死,5例为心肌梗死伴缺血),但其中1例为MVD,通过Tc-99m MIBI检测得出。14例IWMI患者均有下壁灌注缺损(12例为心肌梗死,2例为心肌梗死伴缺血),但其中4例为MVD,通过Tc-99m MIBI检测得出。2例LWMI患者通过Tc-99m MIBI检测显示为侧壁梗死。3例AIWMI患者及1例ALWMI患者通过Tc-99m MIBI检测显示为MVD。IA组11例及IIA组5例AWMI患者的CAG显示左前降支梗死相关血管再通发生率分别为9/11(82%)和4/5(80%),MVD发生率分别为6/11(55%)和0/5(0%)。(摘要截选至400字)