Novelli Giuseppe, Borgiani Paola, Giardina Emiliano, Mango Ruggiero, Contino Gianmarco, Romeo Francesco, Mehta J L
Centre of Excellence for Genomic Risk Assessment in Multifactorial and Complex Diseases, School of Medicine, Tor Vergata University of Rome, Rome, Italy.
Curr Opin Cardiol. 2003 Sep;18(5):368-71. doi: 10.1097/00001573-200309000-00008.
Atherosclerosis is currently regarded as a complex disorder, triggered by gene-gene and gene-environment interactions. Despite the difficulties of multifactorial disease genetic analysis, significant progress has been achieved in the search for atherosclerosis susceptibility genes. Here, we review these advances with regard to genome scan results and candidate gene analysis.
动脉粥样硬化目前被视为一种复杂的病症，由基因-基因和基因-环境相互作用引发。尽管多因素疾病遗传分析存在困难，但在寻找动脉粥样硬化易感基因方面已取得显著进展。在此，我们就基因组扫描结果和候选基因分析方面回顾这些进展。
