Moriya Susumu, Yokoyama Hirokazu, Hirose Hiroshi, Ishii Hiromasa, Saito Ikuo
Department of Internal Medicine, School of Medicine, Keio University, Tokyo, Japan.
Alcohol Clin Exp Res. 2003 Aug;27(8 Suppl):52S-57S. doi: 10.1097/01.ALC.0000078613.67287.B0.
Our previous studies suggested that serum gamma-glutamyl transpeptidase (GGTP) level was correlated with insulin resistance level estimated by the homeostasis model assessment in teetotalers and occasional drinkers. In the surveys, strong correlation between GGTP and triglyceride also was observed. This study examined whether the correlation held true for regular drinkers.
Seven hundred and seventeen male subjects in annual health checkups were divided into three groups according to their drinking styles and further divided into four subgroups according to their serum GGTP levels. In the other surveys, they were ranked by their amount of ethanol consumption. The correlation between GGTP and insulin resistance level was studied in each group.
Single regression analysis and analysis of variance showed that GGTP level was significantly correlated with insulin resistance level as determined by the homeostasis model assessment, as well as with triglyceride level regardless of subjects' drinking styles. The associations were confirmed by multiple regression analyses in which age, levels of uric acid, total cholesterol, high-density lipoprotein cholesterol, and body mass index were adjusted, at least in nondrinkers or light drinkers. However, the multiple regression analyses indicated that the association between GGTP and insulin resistance level was not significant in subjects who take ethanol more than five times per week. The studies according to the amount of subjects' ethanol consumption indicated that the association between GGTP and insulin resistance was significant in the subjects who take ethanol up to 280 g/week.
Individual variation in insulin resistance status may contribute to individual variations of sensitivity of GGTP to ethanol intake, at least in light drinkers.
我们之前的研究表明，在不饮酒者和偶尔饮酒者中，血清γ-谷氨酰转肽酶（GGTP）水平与通过稳态模型评估法估算的胰岛素抵抗水平相关。在这些调查中，还观察到GGTP与甘油三酯之间存在强相关性。本研究探讨了这种相关性在经常饮酒者中是否成立。
717名参加年度健康检查的男性受试者根据饮酒方式分为三组，并根据血清GGTP水平进一步分为四个亚组。在其他调查中，他们按乙醇摄入量进行排名。研究了每组中GGTP与胰岛素抵抗水平之间的相关性。
单因素回归分析和方差分析表明，无论受试者的饮酒方式如何，GGTP水平与通过稳态模型评估法确定的胰岛素抵抗水平以及甘油三酯水平均显著相关。在对年龄、尿酸、总胆固醇、高密度脂蛋白胆固醇和体重指数进行调整的多因素回归分析中，至少在不饮酒者或轻度饮酒者中证实了这种关联。然而，多因素回归分析表明，每周饮酒超过五次的受试者中，GGTP与胰岛素抵抗水平之间的关联不显著。根据受试者乙醇摄入量进行的研究表明，每周乙醇摄入量达280克的受试者中，GGTP与胰岛素抵抗之间存在显著关联。
至少在轻度饮酒者中，胰岛素抵抗状态的个体差异可能导致GGTP对乙醇摄入敏感性的个体差异。
