Dixon K L
Department of Physics, The University of British Colombia, Canada.
Nucl Med Commun. 2003 Sep;24(9):951-7. doi: 10.1097/00006231-200309000-00002.
The treatment of cancer is a wide and varied field, encompassing many methods and modalities. Radioimmunotherapy is a technique which utilizes the ablative properties of radiation by delivering radioactive particles directly to the tumour cells. This paper presents a summary of the research evidence that relates to the optimization of the effect of radioimmunotherapy. It includes discussion on the appropriate choice of radionuclide and monoclonal antibody; methods of increasing the radiation dose absorbed by the tumour; techniques available to increase the effect that the absorbed dose has on the tumour; and methods of protecting critical healthy tissue, particularly the bone marrow, from the effects of the radiation administered.
癌症治疗是一个广泛且多样的领域，涵盖了许多方法和方式。放射免疫疗法是一种通过将放射性粒子直接递送至肿瘤细胞来利用辐射消融特性的技术。本文概述了与优化放射免疫疗法效果相关的研究证据。内容包括关于放射性核素和单克隆抗体的适当选择的讨论；增加肿瘤吸收辐射剂量的方法；可用于增强吸收剂量对肿瘤影响的技术；以及保护关键健康组织，尤其是骨髓免受所施用辐射影响的方法。
