Karakurt Lokman, Yilmaz Erhan, Serin Erhan, Bektaş Bülent, Cikim Gürkan, Gürsu Ferit
Department of Orthopaedics and Traumatology, Firat University, Faculty of Medicine, Elazig, Turkey.
J Pediatr Orthop. 2003 Sep-Oct;23(5):658-60.
The pathogenesis of clubfoot is unknown despite numerous hypotheses. To clarify the relationship between the plasma total homocysteine level and congenital idiopathic clubfoot, blood samples from mothers of children with congenital idiopathic clubfoot (group 1) and mothers of children without congenital anomaly (group 2) were studied. Groups were the same for factors affecting the plasma total homocysteine level. Mean plasma total homocysteine level was 16.34+/-4.78 micromol/L in group 1 and 11.02+/-1.85 micromol/L in group 2, and there was significant statistical difference between the groups (P<0.05). Congenital idiopathic clubfoot showed a significant association with high plasma total homocysteine level. This study may be a step toward clarification of clubfoot pathogenesis.
尽管有众多假说，但马蹄内翻足的发病机制仍不清楚。为了阐明血浆总同型半胱氨酸水平与先天性特发性马蹄内翻足之间的关系，我们对先天性特发性马蹄内翻足患儿的母亲（第1组）和无先天性异常患儿的母亲（第2组）的血样进行了研究。两组在影响血浆总同型半胱氨酸水平的因素方面相同。第1组的平均血浆总同型半胱氨酸水平为16.34±4.78微摩尔/升，第2组为11.02±1.85微摩尔/升，两组之间存在显著统计学差异（P<0.05）。先天性特发性马蹄内翻足与高血浆总同型半胱氨酸水平显著相关。这项研究可能是朝着阐明马蹄内翻足发病机制迈出的一步。
