Gaffuri E, Maranelli G, Romeo L, Durigato S
Istituto di Medicina del Lavoro dell'Università di Verona, Policlinico Borgo Roma.
Med Lav. 1992 Nov-Dec;83(6):596-604.
Smoking habits were studied in a group of employees of a telephone company. The smokers were 34% of the subjects interviewed. The non-smokers said that they were bothered by other people smoking everywhere and also to a considerable extent at the workplace. Differences between smokers and non-smokers and between exposed and non-exposed non-smokers were studied by measuring expired CO and urinary cotinine. An expired CO concentration of 10 ppm discriminated between smokers and non-smokers. A mean urinary cotinine concentration of about 16 ng/mg was found in the exposed non-smokers, corresponding to the direct smoking of 1/10 of a cigarette per day. The search for the metabolic phenotype of destromethorphane, which was taken as an indicator of susceptibility to contract lung cancer due to IPA, showed that there were no differences between smokers and non-smokers since the rapid metabolizers, and therefore subjects potentially exposed to risk of lung cancer due to tobacco smoke, prevailed in both groups.
对一家电话公司的一组员工的吸烟习惯进行了研究。吸烟者占接受访谈对象的34%。不吸烟者表示，他们受到其他人在各处吸烟的困扰，在工作场所也受到相当大的影响。通过测量呼出的一氧化碳（CO）和尿可替宁，研究了吸烟者与不吸烟者之间以及暴露于烟雾与未暴露于烟雾的不吸烟者之间的差异。呼出的CO浓度为10 ppm可区分吸烟者和不吸烟者。在暴露于烟雾的不吸烟者中，尿可替宁的平均浓度约为16 ng/mg，相当于每天直接吸1/10支香烟。以右美沙芬的代谢表型作为因异丙醇接触而患肺癌易感性的指标进行研究，结果表明吸烟者和不吸烟者之间没有差异，因为两组中快速代谢者（即可能因烟草烟雾而面临肺癌风险的人群）占多数。
