Rudolph Karin, Bice David E, Hey John A, McLeod Robbie L
Respiratory Immunology Program, Lovelace Respiratory, Research Institute Albuquerque, New Mexico 87108, USA.
Am J Rhinol. 2003 Jul-Aug;17(4):227-32.
Acoustic rhinometry is a noninvasive method that uses sound waves to measure dimensions of the nasal cavity.
In this study, nasal patency was measured by acoustic rhinometry in allergic Beagle dogs sensitized to ragweed allergen. Ragweed (0.03-0.3%) or vehicle were administered intranasally in isoflurane-anesthetized dogs.
The instillation of ragweed caused a dose-related decrease in nasal cavity volume and minimal cross-sectional area (Amin) without adverse systemic effects. Nasal cavity volume and Amin decreased within 30 minutes after instillation of the highest ragweed dose by 35.1 +/- 6.0% and 66.4 +/- 13.8%, respectively, and persisted for at least 90 minutes. Oral administration of alpha-adrenergic agonist, d-pseudoephedrine (3 mg/kg), or histamine H1 antagonist chlorpheniramine (10 mg/ kg) blocked the ragweed-induced nasal congestion.
These results suggest that the canine model may be used to study upper-airway diseases such as allergic rhinitis and to evaluate the pharmacologic activity of nasal decongestants.
鼻声反射测量法是一种利用声波测量鼻腔尺寸的非侵入性方法。
在本研究中，通过鼻声反射测量法对豚草过敏原致敏的过敏性比格犬的鼻腔通畅情况进行测量。将豚草（0.03 - 0.3%）或赋形剂经鼻给予异氟烷麻醉的犬。
滴入豚草导致鼻腔容积和最小横截面积（Amin）呈剂量相关下降，且无全身不良反应。滴入最高剂量豚草后30分钟内，鼻腔容积和Amin分别下降35.1±6.0%和66.4±13.8%，并持续至少90分钟。口服α - 肾上腺素能激动剂d - 伪麻黄碱（3毫克/千克）或组胺H1拮抗剂氯苯那敏（10毫克/千克）可阻断豚草诱导的鼻充血。
这些结果表明，犬模型可用于研究诸如过敏性鼻炎等上呼吸道疾病，并评估鼻减充血剂的药理活性。
