Kennedy Ronald C, Shearer Michael H
Department of Microbiology and Immunology, Texas Tech University Health Sciences Center, Lubbock, Texas 79430, USA.
Int Rev Immunol. 2003 Mar-Apr;22(2):141-72. doi: 10.1080/08830180305222.
Recent advances have demonstrated the clinical utility of specific monoclonal antibodies that recognize tumor-associated antigens on the surface of the tumor cell in the treatment of breast cancer and B cell lymphoma in humans. In addition to these studies, an experimental tumor model, where antibodies that recognize a viral-encoded tumor-specific antigen play a major role in tumor immunity, will be discussed. Together, these studies implicate antibodies as a means of providing tumor immunity against some cancers. The necessity for designing cancer vaccines that induce antibodies with specificity for antigens on the tumor cell will be discussed.
最近的进展已经证明，在治疗人类乳腺癌和B细胞淋巴瘤方面，识别肿瘤细胞表面肿瘤相关抗原的特异性单克隆抗体具有临床实用性。除了这些研究之外，还将讨论一种实验性肿瘤模型，在该模型中，识别病毒编码肿瘤特异性抗原的抗体在肿瘤免疫中起主要作用。这些研究共同表明，抗体是提供针对某些癌症的肿瘤免疫的一种手段。将讨论设计能诱导产生对肿瘤细胞抗原具有特异性的抗体的癌症疫苗的必要性。
