Association between anatomopathologic graft disorders during reperfusion and vena cava sIL-2r in orthotopic liver transplantation.

作者信息

Arranz J, Soriano A, Garcia I, Garcia I, Concepción M T, Navarro J, Arteaga A, Filella X, Gonzalez F, Fernández C, Barrera M, Muñoz L, Perera A J, Pozo J L, Jiménez A, Macia M, Arteaga I

机构信息

Liver Transplant Unit, Research Unit, University Hospital Clinic (Barcelona), University Hospital NS de Candelaria, Tenerife, Spain.

出版信息

Transplant Proc. 2003 Aug;35(5):1880-3. doi: 10.1016/s0041-1345(03)00721-8.

DOI:10.1016/s0041-1345(03)00721-8

PMID:12962833

Abstract

UNLABELLED

Graft ischemia-reperfusion injury during orthotopic liver transplantation (OLT) is associated with anatomic and pathologic disorders in the graft, which may cause initial dysfunction. The object of this paper was to evaluate sIL-2r as an indicator of liver damage during graft reperfusion.

MATERIAL AND METHODS

Blood samples were drawn from 20 consecutive patients who required OLT secondary to chronic end-stage insufficiency various sites (portal vein, vena cava, pulmonary artery) and during different surgical phases. Following centrifugation and storage at -70 degrees C, sIL-2r was quantitated by chemiluminescence (Immulite, EURO/DPC). In addition biopsies were graded from 0 to III according to the anatomic and pathologic findings. Base excess and ammonia were measured to evaluate the function of the new liver.

STATISTICAL ANALYSES

Parameter associations were explored using Spearman's Rho and Kendall's Tau-b methods.

RESULTS

There was a correlation between the degree of graft preservation and sIL-2R both during vena cava reperfusion (r=.0591, P=.05) and for the initial 2 hours after reperfusion (r=0.61, P=.062).