Novák M, Psenicka M, Smola M, Bultas J, Cermák S
II. interní klinika 1. LF UK, Praha.
Vnitr Lek. 1992 Dec;38(12):1172-80.
Rate responsive cardiac pacemakers adapting their pacing frequency according to physical effort are able to solve not only a bradycardia, but a chronotropic incompetence too. 23 rate responsive pulse generators, implanted in 1987-1991 in our center, simulated the physiological conditions and in this way they significantly improved both working capacity in bicycle stress test (p < 0.0001) and well-being in comparison with ordinary demand pacers. The incidence of complications did not exceed that in simple common pacemakers, but the rate adaptive ones were expensive and their programming was time consuming. In all three rate adaptive principles used their non-specific response revealed some imperfection of sensor driven devices. In addition, both in QT and in respiratory dependent systems their pretty proportional frequency response was delayed, while the irregular pacing rate in body activity sensor was not very proportionate to the physical exercise. The non-specific sensor response may be reduced by a combination of biologic sensors.
根据体力活动调整起搏频率的频率应答式心脏起搏器不仅能够解决心动过缓问题，还能解决变时性功能不全问题。1987年至1991年在我们中心植入的23个频率应答式脉冲发生器模拟了生理状况，通过这种方式，与普通按需起搏器相比，它们显著提高了自行车运动试验中的工作能力（p < 0.0001）和舒适度。并发症的发生率不超过普通简单起搏器，但频率自适应起搏器价格昂贵且编程耗时。在使用的所有三种频率自适应原理中，其非特异性反应显示出传感器驱动装置存在一些缺陷。此外，在QT和呼吸依赖系统中，它们相当成比例的频率反应都有延迟，而身体活动传感器中不规则的起搏频率与体育锻炼的比例不太相称。生物传感器的组合可能会减少非特异性传感器反应。
