澳大利亚昆士兰州肾移植后非黑色素瘤皮肤癌的相关因素。

Factors associated with nonmelanoma skin cancer following renal transplantation in Queensland, Australia.

作者信息

Ramsay Helen M, Fryer Anthony A, Hawley Carmel M, Smith Andrew G, Nicol David L, Harden Paul N

机构信息

Department of Dermatology, Centre for Cell and Molecular Medicine, School of Medicine, Keele University, North Staffordshire Hospital, Stoke-on-Trent, United Kingdom.

出版信息

J Am Acad Dermatol. 2003 Sep;49(3):397-406. doi: 10.1067/s0190-9622(03)00902-2.

DOI:10.1067/s0190-9622(03)00902-2

PMID:12963901

Abstract

BACKGROUND

Caucasian renal transplant recipients living in Queensland, Australia, have the highest risk of nonmelanoma skin cancer in the world.

OBJECTIVE

To determine clinical and environmental factors associated with posttransplantation nonmelanoma skin cancer in Queensland.

METHODS

361 Caucasian adult recipients completed a structured interview and full skin examination. Skin cancer details were obtained from hospital records.

RESULTS

Squamous cell carcinoma was strongly associated with blue or hazel eyes, time resident in a hot climate, and pretransplantation squamous cell carcinoma; tumor numbers were associated with birth in a hot climate, childhood sunburn, pretransplantation actinic keratoses, and smoking. The risk of basal cell carcinoma was strongly associated with acute or intermittent sun exposure during childhood and pretransplantation basal cell carcinoma; numbers were associated with blue or hazel eyes, time spent living in a hot climate, and male gender.

CONCLUSION

Clinical and environmental factors can be used to identify recipients at risk of nonmelanoma skin cancer in Queensland.

摘要

背景

居住在澳大利亚昆士兰州的白种人肾移植受者患非黑素瘤皮肤癌的风险是全球最高的。

目的

确定昆士兰州与移植后非黑素瘤皮肤癌相关的临床和环境因素。

方法

361名成年白种人受者完成了结构化访谈和全面的皮肤检查。皮肤癌细节从医院记录中获取。

结果

鳞状细胞癌与蓝眼睛或淡褐色眼睛、在炎热气候地区居住的时间以及移植前的鳞状细胞癌密切相关；肿瘤数量与在炎热气候地区出生、儿童期晒伤、移植前光化性角化病以及吸烟有关。基底细胞癌的风险与儿童期急性或间歇性日晒以及移植前的基底细胞癌密切相关；数量与蓝眼睛或淡褐色眼睛、在炎热气候地区居住的时间以及男性性别有关。