皮肤鳞状细胞癌的分化程度：瑞典器官移植受者队列与免疫功能正常患者的比较

Degree of differentiation of cutaneous squamous cell carcinoma: a comparison between a Swedish cohort of organ transplant recipients and immunocompetent patients.

作者信息

Stenman Caroline, Gonzalez Helena, Gillstedt Martin, Dellgren Göran, Hasséus Bengt, Holmberg Erik, Rexius Helena, Öhman Jenny, Paoli John

机构信息

Department of Dermatology and Venereology, Institute of Clinical Sciences, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden.

Department of Cardiothoracic Surgery and Transplant Institute, Sahlgrenska University Hospital, Gothenburg, Sweden.

出版信息

Dermatol Pract Concept. 2018 Oct 31;8(4):330-336. doi: 10.5826/dpc.0804a18. eCollection 2018 Oct.

DOI:10.5826/dpc.0804a18

PMID:30479868

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC6246062/

Abstract

BACKGROUND

Organ transplant recipients (OTRs) have a very high risk of developing cutaneous squamous cell carcinoma (cSCC). Immunosuppressed OTRs may have a higher proportion of poorly differentiated cSCC than non-OTRs.

OBJECTIVES

The aim of this study was to investigate the degree of differentiation of cSCCs in OTRs compared with immunocompetent individuals.

PATIENTS/METHODS: Data from the Swedish Cancer Registry were crosschecked with data from the Transplant registry of the Transplant Institute at Sahlgrenska University Hospital in Gothenburg, Sweden. All OTRs with a diagnosis of cSCC, basosquamous carcinoma, and/or cSCC in situ established at the Department of Dermatology, Sahlgrenska University Hospital, during 2002-2015 were included. The control group consisted of non-OTRs with the same diagnoses during the same time period.

RESULTS

During 2002-2015, 82 OTRs diagnosed with 515 tumors and 883 non-OTRs with 1,247 tumors were included. OTRs developed 0.47 tumors/year vs 0.10 tumors/year for non-OTRs, but no significant differences were observed in the degree of tumor differentiation of invasive cSCCs between OTRs and non-OTRs (P = 0.4). The distribution of poorly, moderately, and well-differentiated invasive cSCCs among OTRs and non-OTRs were 8.5% vs 12.5%, 22.1% vs 29.9%, and 69.4% vs 57.6%, respectively.

CONCLUSIONS

OTRs do not develop a higher proportion of poorly differentiated cSCCs than non-OTRs.

摘要

背景

器官移植受者（OTR）发生皮肤鳞状细胞癌（cSCC）的风险非常高。免疫抑制的OTR发生低分化cSCC的比例可能高于非OTR。

目的

本研究旨在调查与免疫功能正常个体相比，OTR中cSCC的分化程度。

患者/方法：瑞典癌症登记处的数据与瑞典哥德堡萨尔格伦斯卡大学医院移植研究所的移植登记处的数据进行了交叉核对。纳入2002年至2015年期间在萨尔格伦斯卡大学医院皮肤科确诊为cSCC、基底鳞状细胞癌和/或原位cSCC的所有OTR。对照组由同期患有相同诊断的非OTR组成。

结果

2002年至2015年期间，纳入了82名诊断出515个肿瘤的OTR和883名诊断出1247个肿瘤的非OTR。OTR每年发生0.47个肿瘤，而非OTR为每年0.10个肿瘤，但OTR和非OTR之间浸润性cSCC的肿瘤分化程度未观察到显著差异（P = 0.4）。OTR和非OTR中低分化、中分化和高分化浸润性cSCC的分布分别为8.5%对12.5%、22.1%对29.9%和69.4%对57.6%。