Krämer S C, Görich J, Oertel F, Scheld H, Heindel W
Institut für Klinische Radiologie, Universitätsklinikum Münster.
Rofo. 2003 Sep;175(9):1177-83. doi: 10.1055/s-2003-41923.
The so-called non-occlusive disease (NOD) or non-occlusive mesenteric ischemia (NOMI) is a severe and life-threatening pathology. Even under optimal circumstances and standardised diagnostic and therapeutic procedures maximum survival rates do not exceed 50 %. The NOD is a pathology of the elder patient and its incidence rises with other comorbidities such as reduced cardiac output, diabetes and renal insufficiency. Induction of the disease with a severe vasoconstriction of the splanchnic vessels may be a simple cardiac decompensation, a frequent trigger however is a previous heart surgery with consecutive cardiac shock. Early diagnosis is difficult to conduct because of unspecific symptoms. Beside abdominal pain in awake patients, ileus or subileus is remaining the single acute symptom which could be also a consequence of a postoperative paralysis. Laboratory parameters such as leucocytosis and elevated lactat levels are often positive, but unspecific and the latter may be a delayed sign of progressive disease. The only sufficient method for diagnosis implicating a possible treatment option seems to be an immediate angiographic examination. Because of the disappointing results of a solitary surgical approach transarterial medication via catheter is indicated. Depending of the course of the disease only a combination of local mesenteric infusion of vasodilatory drugs and surgical resection of already necrotic bowel promises a successful therapeutic approach and better survival rates.
所谓的非闭塞性疾病(NOD)或非闭塞性肠系膜缺血(NOMI)是一种严重的、危及生命的病症。即使在最佳情况下以及采用标准化的诊断和治疗程序,最高生存率也不超过50%。NOD是老年患者的一种病症,其发病率会随着诸如心输出量减少、糖尿病和肾功能不全等其他合并症而上升。内脏血管严重血管收缩引发该疾病可能只是单纯的心功能不全,但常见的诱因是先前的心脏手术及随之而来的心源性休克。由于症状不具特异性,早期诊断很难进行。除了清醒患者的腹痛外,肠梗阻或亚肠梗阻是唯一的急性症状,这也可能是术后麻痹的结果。诸如白细胞增多和乳酸水平升高之类的实验室指标通常呈阳性,但不具特异性,而且后者可能是疾病进展的一个延迟迹象。唯一足以进行诊断并暗示可能治疗方案的方法似乎是立即进行血管造影检查。由于单纯手术方法的结果令人失望,因此建议通过导管进行经动脉给药。根据疾病的病程,只有局部肠系膜输注血管扩张药物与对已坏死肠段进行手术切除相结合,才有望实现成功的治疗方法并提高生存率。