Petersen Timothy J, Alpert Jonathan E, Papakostas George I, Bernstein Emily M, Freed Rachel, Smith Megan M, Fava Maurizio
Depression Clinical and Research Program, Massachusetts General Hospital, Boston, Massachusetts 02114, USA.
Depress Anxiety. 2003;18(2):104-8. doi: 10.1002/da.10118.
We compared the emotional and behavioral characteristics of offspring of parents with early-onset depression and the offspring of parents with late-onset depression. Forty-three parents who met criteria for major depressive disorder (MDD) completed the Achenbach Child Behavior Checklist-Parent Report Version (CBCL) for a birth child (n=43, age range 6-17 years). Parents were classified as having either early SD onset (<19 years) or late-onset (> or = 19 years) MDD based on responses gathered during the SCID-P interview. Unpaired t-tests were used to compare the two offspring groups on CBCL clinical and competency scales. Chi-square analyses and unpaired t-tests were used to compare the two parent groups on demographic and clinical features. Offspring of parents with early-onset depression scored significantly higher on the majority of the CBCL clinical scale scores when compared with offspring of parents with late-onset depression, rated as exhibiting higher levels of the characteristics measured: withdrawn, anxious/depressed, social problems, thought problems, attention problems, delinquent behavior, and aggressive behavior. Additionally, this group had a significantly higher total T score (a global measure of psychopathology) and significantly lower social functioning. Children of parents with early-onset depression may be at higher risk for behavioral and emotional problems than offspring of parents with late-onset depression. This finding may be significant in uncovering sources of vulnerability and formulating intervention strategies for offspring of depressed parents.
我们比较了早发性抑郁症父母的子女与晚发性抑郁症父母的子女的情绪和行为特征。43名符合重度抑郁症（MDD）标准的父母为其亲生子女（n = 43，年龄范围6 - 17岁）完成了阿肯巴克儿童行为量表家长报告版（CBCL）。根据在SCID - P访谈中收集的回答，父母被分类为患有早发性（<19岁）或晚发性（≥19岁）MDD。采用独立样本t检验比较两组子女在CBCL临床量表和能力量表上的得分。使用卡方分析和独立样本t检验比较两组父母在人口统计学和临床特征方面的差异。与晚发性抑郁症父母所生子女相比，早发性抑郁症父母所生子女在大多数CBCL临床量表得分上显著更高，被评定为表现出更高水平的所测量特征：退缩、焦虑/抑郁、社交问题、思维问题、注意力问题、违纪行为和攻击行为。此外，该组的总T分数（心理病理学的综合测量指标）显著更高，社交功能显著更低。早发性抑郁症父母的子女可能比晚发性抑郁症父母的子女面临更高的行为和情绪问题风险。这一发现对于揭示易感性来源以及为抑郁症父母的子女制定干预策略可能具有重要意义。
