CagA状态对日本幽门螺杆菌感染儿童血清胃泌素及胃蛋白酶原I和II浓度的影响

Impact of CagA status on serum gastrin and pepsinogen I and II concentrations in Japanese children with Helicobacter pylori infection.

作者信息

Fukuda Y, Isomoto H, Ohnita K, Omagari K, Mizuta Y, Murase K, Murata I, Moriuchi H, Kohno S

机构信息

Second Department of Internal Medicine, Nagasaki University School of Medicine, Nagasaki University Graduate School of Pharmaceutical Sciences, Nagasaki, Japan.

出版信息

J Int Med Res. 2003 Jul-Aug;31(4):247-52. doi: 10.1177/147323000303100401.

DOI:10.1177/147323000303100401

PMID:12964499

Abstract

The study aimed to determine the association between cytotoxin-associated gene product (CagA), serum gastrin and pepsinogen levels in Japanese children infected with Helicobacter pylori. Three hundred children were enrolled in the study. H. pylori infection was assessed using an enzyme-linked immunosorbent assay, and CagA status was assessed using immunoblotting. Serum gastrin and pepsinogen concentrations were measured by radioimmunoassay. H. pylori seroprevalence was 12.3% (37/300) and CagA status was identified in 28/37 H. pylori-seropositive children (75.7%). Serum pepsinogen I and II levels were significantly higher in CagA-seropositive than CagA-seronegative children with H. pylori infection. There was no significant relationship between CagA seropositivity and serum gastrin levels. In conclusion, CagA status has a significant impact on serum pepsinogen levels, possibly through enhanced gastric mucosal inflammation.

摘要

该研究旨在确定感染幽门螺杆菌的日本儿童中细胞毒素相关基因产物（CagA）、血清胃泌素和胃蛋白酶原水平之间的关联。300名儿童参与了该研究。采用酶联免疫吸附测定法评估幽门螺杆菌感染情况，采用免疫印迹法评估CagA状态。通过放射免疫测定法测量血清胃泌素和胃蛋白酶原浓度。幽门螺杆菌血清阳性率为12.3%（37/300），在37名幽门螺杆菌血清阳性儿童中有28名（75.7%）确定了CagA状态。在感染幽门螺杆菌的儿童中，CagA血清阳性儿童的血清胃蛋白酶原I和II水平显著高于CagA血清阴性儿童。CagA血清阳性与血清胃泌素水平之间无显著关系。总之，CagA状态可能通过增强胃黏膜炎症对血清胃蛋白酶原水平产生显著影响。