Nabekura Tomohiro, Minami Takeshi, Hirunuma Rieko, Enomoto Shuichi, Tomohiro Masayuki, Ito Yoshimasa, Kitagawa Shuji
Faculty of Pharmaceutical Sciences, Niigata University of Pharmacy and Applied Life Sciences, Kamishin'ei-cho, Niigata, 950-2081, Japan.
Toxicology. 2003 Sep 30;191(2-3):227-32. doi: 10.1016/s0300-483x(03)00261-0.
The multitracer technique was applied to the determination of the uptake of trace elements in the lenses of normal and hereditary cataract UPL rats to investigate the transport mechanisms of trace elements during cataract development. Be, Na, Sc, V, Cr, Mn, Fe, Co, Zn, As, Se, Rb, Sr, Y, Zr, Tc, Ru and Rh accumulate in normal and UPL cataract rat lenses. The rates of uptake of trace elements differ among species and also differ between normal and UPL rat lenses. The uptakes of V and Sr are greater in normal rat lenses, while the uptakes of Mn and Co are greater in UPL rat lenses. High concentrations of Zn are transported into normal rat lenses in comparison with other elements. However, the uptake of Se was highest in the lenses of UPL cataract rats. In addition, the difference in Se uptake between the normal and UPL rat lenses was greatest among the tested trace elements. The present study suggests that the transport characteristics of trace elements are different in the lenses of normal and UPL cataract rats. The different transport characteristics of trace elements in the lenses of normal and UPL cataract rats, especially the higher accumulation of Se in UPL rat lenses, may be implicated in cataract development.
采用多示踪技术测定正常和遗传性白内障UPL大鼠晶状体中微量元素的摄取情况，以研究白内障形成过程中微量元素的转运机制。铍、钠、钪、钒、铬、锰、铁、钴、锌、砷、硒、铷、锶、钇、锆、锝、钌和铑在正常和UPL白内障大鼠晶状体中均有蓄积。微量元素的摄取速率因物种而异，正常大鼠和UPL大鼠晶状体之间也存在差异。钒和锶在正常大鼠晶状体中的摄取量较大，而锰和钴在UPL大鼠晶状体中的摄取量较大。与其他元素相比，高浓度的锌被转运到正常大鼠晶状体中。然而，硒在UPL白内障大鼠晶状体中的摄取量最高。此外，在测试的微量元素中，正常大鼠和UPL大鼠晶状体之间硒摄取的差异最大。本研究表明，正常和UPL白内障大鼠晶状体中微量元素的转运特征不同。正常和UPL白内障大鼠晶状体中微量元素不同的转运特征，尤其是硒在UPL大鼠晶状体中的较高蓄积，可能与白内障的形成有关。
