Russell Aaron P, Gastaldi Giacomo, Bobbioni-Harsch Elisabetta, Arboit Patrizia, Gobelet Charles, Dériaz Olivier, Golay Alain, Witztum Joseph L, Giacobino Jean-Paul
Clinique Romande de Réadaptation SUVA Care, Case postale 352, 1951 Sion, Switzerland.
FEBS Lett. 2003 Sep 11;551(1-3):104-6. doi: 10.1016/s0014-5793(03)00875-5.
Intra-myocellular triglycerides (IMTG) accumulate in the muscle of obese and endurance-trained (ET) humans and are considered a pathogenic factor in the development of insulin resistance, in the former. We postulate that this paradox may be associated with the peroxidation status of the IMTG. IMTG content was the same in the obese and ET subjects. The lipid peroxidation/IMTG ratio was 4.2-fold higher in the obese subjects. Hence, obesity results in an increased level of IMTG peroxidation while ET has a protective effect on IMTG peroxidation. This suggests a link between the lipid peroxidation/IMTG ratio and insulin resistance.
细胞内甘油三酯（IMTG）在肥胖和耐力训练（ET）人群的肌肉中蓄积，在前一种人群中，IMTG被认为是胰岛素抵抗发生发展的致病因素。我们推测，这种矛盾现象可能与IMTG的过氧化状态有关。肥胖和ET受试者的IMTG含量相同。肥胖受试者的脂质过氧化/IMTG比值高4.2倍。因此，肥胖导致IMTG过氧化水平升高，而ET对IMTG过氧化具有保护作用。这表明脂质过氧化/IMTG比值与胰岛素抵抗之间存在联系。
