Mena-Segovia Juan, Giordano Magda
Department of Behavioral and Cognitive Neurobiology, Instituto de Neurobiología, Campus UNAM Juriquilla, 76230, Querétaro, QRO 76230, Mexico.
Brain Res. 2003 Oct 3;986(1-2):30-8. doi: 10.1016/s0006-8993(03)03167-6.
Striatal activation can modify activity in cortical areas related to specific striatal functions possibly through a process of disinhibition within the basal ganglia. Anatomical studies have shown substantial GABAergic innervation from these nuclei to the pedunculopontine tegmental nucleus (PPT). Thus, dopaminergic stimulation of the striatum could produce PPT disinhibition and result in non-specific cortical activation. To test this hypothesis, d-amphetamine was infused both into the striatum of freely moving rats for motor and electrocorticographic recordings, and into the striatum of animals under deep anesthesia for c-Fos immunohistochemistry. The results show that intrastriatal amphetamine increases wakefulness independent of motor activity, and it increases c-Fos expression in the PPT and adjacent areas. They also suggest that the striatum participates in non-specific cortical activation probably as a result of its relationship with the PPT.
纹状体激活可能通过基底神经节内的去抑制过程来改变与特定纹状体功能相关的皮质区域的活动。解剖学研究表明，这些核团对脚桥被盖核（PPT）有大量的γ-氨基丁酸能神经支配。因此，纹状体的多巴胺能刺激可导致PPT去抑制，并引起非特异性皮质激活。为了验证这一假设，将d-苯丙胺注入自由活动大鼠的纹状体以进行运动和脑电图记录，并注入深度麻醉动物的纹状体以进行c-Fos免疫组织化学检测。结果表明，纹状体内注入苯丙胺可增加清醒程度，且与运动活动无关，同时增加了PPT及相邻区域的c-Fos表达。这些结果还表明，纹状体可能因其与PPT的关系而参与非特异性皮质激活。
