雌激素无法保护雌性大鼠的黑质致密部免受6-羟基多巴胺诱导的损伤。
Failure of estrogen to protect the substantia nigra pars compacta of female rats from lesion induced by 6-hydroxydopamine.
作者信息
Ferraz Anete Curte, Xavier Léder Leal, Hernandes Sílvia, Sulzbach Martha, Viola Giordano Gubert, Anselmo-Franci Janete A, Achaval Matilde, Da Cunha Claudio
机构信息
Laboratório de Fisiologia e Farmacologia do Sistema Nervoso Central, Departamento de Fisiologia e Farmacologia, Universidade Federal do Paraná, CP 19.031, 81.531-990 Curitiba, PR, Brazil.
出版信息
Brain Res. 2003 Oct 3;986(1-2):200-5. doi: 10.1016/s0006-8993(03)03198-6.
The immunostaining for tyrosine hydroxylase (TH) in the substantia nigra pars compacta (SNpc) and in the ventral tegmental area (VTA) after intranigral infusion of 6-hydroxydopamine (6-OHDA, 6 microg/side) was analyzed in ovariectomized adult female Wistar rats. Estrogen replacement for 52 days (400-microg 17-beta-estradiol capsules) did not prevent the loss of TH-immunoreactive cells induced by 6-OHDA in the SNpc. This result indicates that the neuroprotective effect of dopaminergic mesencephalic cells is not observed with long-term estrogen replacement.
在成年去卵巢雌性Wistar大鼠中，分析了黑质致密部（SNpc）和腹侧被盖区（VTA）经脑内注射6-羟基多巴胺（6-OHDA，6微克/侧）后酪氨酸羟化酶（TH）的免疫染色情况。用52天（400微克17-β-雌二醇胶囊）进行雌激素替代并不能预防6-OHDA诱导的SNpc中TH免疫反应性细胞的丢失。该结果表明，长期雌激素替代未观察到对多巴胺能中脑神经元的神经保护作用。
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