Ri-Li Ge, Chase Paul J, Witkowski Sarah, Wyrick Brenda L, Stone Jeff A, Levine Benjamin D, Babb Tony G
Institute for Exercise and Environmental Medicine, Presbyterian Hospital of Dallas, Texas 75231, USA.
Ann Intern Med. 2003 Aug 19;139(4):253-7. doi: 10.7326/0003-4819-139-4-200308190-00007.
Although few retrospective studies of high altitude have reported that obesity might be associated with the development of acute mountain sickness (AMS), this association has not been studied prospectively.
To determine whether obesity is associated with the development of AMS.
Obese and nonobese men were compared at a simulated altitude of 3658 m (12 000 ft).
24 hours in a hypobaric environmental chamber.
9 obese and 10 nonobese men.
Percentage body fat (by hydrostatic weighing), Lake Louise AMS score, and Sao2 level (by pulse oximetry) were measured.
Average AMS scores increased more rapidly with time spent at simulated high altitudes for obese men than for nonobese men (P < 0.001). The response of Sao2 with exposure differed between nonobese and obese men. After 24 hours in the altitude chamber, seven obese men (78%) and four nonobese men (40%) had AMS scores of 4 or more.
Obesity seems to be associated with the development of AMS, which may be partly related to greater nocturnal desaturation with altitude exposure.
尽管少数关于高原的回顾性研究报告称肥胖可能与急性高原病（AMS）的发生有关，但尚未对这种关联进行前瞻性研究。
确定肥胖是否与AMS的发生有关。
在模拟海拔3658米（12000英尺）的高度对肥胖男性和非肥胖男性进行比较。
在低压环境舱内进行24小时观察。
9名肥胖男性和10名非肥胖男性。
测量体脂百分比（通过水下称重法）、路易斯湖AMS评分和血氧饱和度水平（通过脉搏血氧饱和度测定法）。
在模拟高海拔环境中，肥胖男性的平均AMS评分随时间增加的速度比非肥胖男性更快（P<0.001）。非肥胖男性和肥胖男性在暴露后血氧饱和度的反应有所不同。在海拔舱内停留24小时后，7名肥胖男性（78%）和4名非肥胖男性（40%）的AMS评分达到4分或更高。
肥胖似乎与AMS的发生有关，这可能部分与海拔暴露导致的夜间更大程度的血氧饱和度降低有关。
