Rifai K, Bahr M J
Abteilung Gastroenterologie, Hepatologie und Endokrinologie, Medizinische Hochschule Hannover.
Internist (Berl). 2003 May;44(5):585-90, 592-8. doi: 10.1007/s00108-003-0914-8.
Acute liver failure is characterized by a dynamic clinical course associated with high mortality. The main prognostic determinant is the development of extrahepatic complications. Close monitoring is mandatory, and prophylactic measures to avoid complications should be initiated. In case of complications, early and aggressive treatment is indicated. To date, artificial liver support devices are still in the experimental phase. Liver transplantation should be considered in patients with predictors of a poor spontaneous prognosis. Therefore, a transplant center should be contacted in every case of acute liver failure.
急性肝衰竭的特点是临床病程动态变化且死亡率高。主要的预后决定因素是肝外并发症的发生。必须进行密切监测，并应启动预防措施以避免并发症。一旦出现并发症，应进行早期积极治疗。迄今为止，人工肝支持装置仍处于实验阶段。对于有自发预后不良预测因素的患者，应考虑肝移植。因此，每例急性肝衰竭患者均应联系移植中心。
