Bukharin O V, Nemtseva N V
Institute of Cellular and Intracellular Symbiosis, Orenburg, Russia.
Zh Mikrobiol Epidemiol Immunobiol. 2003 Jul-Aug(4):27-31.
The role of enzyme--substrate interactions for the survival of bacteria in natural biocenoses has been analyzed with the systems "lysozyme-antilysozyme", "histon-antihiston" used as models. The conception of a possible universal mechanism for supporting the circulation of pathogenic and opportunistic microorganisms among eukaryotes, irrespective of their evolutionary status and environment, has been formulated. This mechanism is ensured by the natural resistance of the eukaryotic cells and by persistence factors on the part of the pathogen; as a result, the dynamic system of interactions is formed which facilitates the survival of microorganisms due to their persistence potential. New knowledge thus obtained opens prospects in the study of sanitary and ecological aspects of water biocenoses.
以“溶菌酶 - 抗溶菌酶”、“组蛋白 - 抗组蛋白”系统为模型，分析了酶 - 底物相互作用在天然生物群落中细菌生存的作用。提出了一种可能的通用机制概念，用于支持致病和机会性微生物在真核生物中的循环，而不论其进化地位和环境如何。这种机制由真核细胞的天然抗性和病原体方面的持续因素保证；结果，形成了相互作用的动态系统，由于微生物的持续潜力而促进了它们的生存。由此获得的新知识为水生物群落的卫生和生态方面的研究开辟了前景。
