Ishikawa T, Funatsu N, Nakanishi O, Maekawa T, Sakabe T
Department of Anesthesiology Resuscitology, Yamaguchi University, School of Medicine, Japan.
No To Shinkei. 1992 Nov;44(11):1017-20.
The effects of isosorbide dinitrate (ISDN) on regional cerebral blood flow (rCBF) and intracranial pressure (ICP) were examined in cats. A low dose of ISDN (2.5 micrograms/kg/min) infusion did not show any changes in cerebral hemodynamics. During high dose of ISDN (5.0 micrograms/kg/min) or NTP (5.0 micrograms/kg/min) infusion, mean blood pressure (mBP) decreased by 10 to 20% accompanied by decreased cerebral perfusion pressure (CPP: mBP-ICP), however, rCBF or ICP did not change. It is concluded that intravenous administrations of ISDN in a dose of 2.5-5.0 micrograms/kg/min that produce slight decrease in blood pressure did not influence on cerebral hemodynamics.
在猫身上研究了硝酸异山梨酯（ISDN）对局部脑血流量（rCBF）和颅内压（ICP）的影响。低剂量ISDN（2.5微克/千克/分钟）输注未显示脑血流动力学有任何变化。在高剂量ISDN（5.0微克/千克/分钟）或NTP（5.0微克/千克/分钟）输注期间，平均血压（mBP）下降10%至20%，同时脑灌注压（CPP：mBP-ICP）降低，然而，rCBF或ICP并未改变。得出结论，静脉注射剂量为2.5 - 5.0微克/千克/分钟的ISDN，虽使血压略有下降，但对脑血流动力学无影响。
