Yazici Mustafa, Demircan Sabri, Aksakal Emre, Sahin Mahmut, Meriç Murat, Dursun Ihsan, Yüksel Serkan, Sağkan Olcay
Department of Cardiology, Medical Faculty, Ondokuz Mayis University, Samsun.
Anadolu Kardiyol Derg. 2003 Sep;3(3):222-6.
High baseline insulin and glucose levels and presence of accompanying dyslipidemia, which are considered in the pathogenesis of metabolic syndrome X, were also observed in patients with cardiac syndrome X, which is similar to metabolic syndrome X in many aspects. In this study we aimed to compare serum insulin, glucose and lipid levels in patients with coronary slow flow which is hypothesized as a subgroup of cardiac syndrome X with those of healthy subjects and determine the relation of corrected TIMI frame count (cTFC) with these levels.
Forty-six patients with normal epicardial coronary arteries but determined as coronary slow flow in coronary angiography performed because of chest pain and 16 healthy subjects having normal coronary arteries but without coronary slow flow were included in this study. Maximal exercise stress test according to Bruce protocol was performed in all patients. Baseline serum insulin, glucose and lipid levels were measured from venous blood samples of patients in both groups. TIMI 'frame count' method was used for diagnosis of coronary slow flow. The relationship between the degree of coronary slow flow and serum insulin, glucose and lipid levels was investigated.
Exercise stress test results of both groups were considered as negative regarding ischemia. There were no differences between 2 groups in serum insulin, glucose and lipid levels. (p>0.05). No relationship were determined by correlations analysis between serum insulin, glucose and lipid levels and corrected TIMI frame count.
Normal values of insulin, glucose and lipid levels in patients with coronary slow flow and lack of their relation with cTFC support the opinion that coronary slow flow is a separate from the cardiac syndrome X clinical entity.
在心脏综合征X患者中也观察到了高基线胰岛素和血糖水平以及伴随的血脂异常，这些在X综合征的发病机制中被认为是相关因素，心脏综合征X在许多方面与代谢综合征X相似。在本研究中，我们旨在比较被假设为心脏综合征X一个亚组的冠状动脉慢血流患者与健康受试者的血清胰岛素、血糖和血脂水平，并确定校正的心肌梗死溶栓治疗（TIMI）帧数计数（cTFC）与这些水平之间的关系。
本研究纳入了46例因胸痛进行冠状动脉造影时被确定为冠状动脉慢血流但心外膜冠状动脉正常的患者，以及16例冠状动脉正常但无冠状动脉慢血流的健康受试者。所有患者均按照Bruce方案进行了最大运动负荷试验。从两组患者的静脉血样本中测量基线血清胰岛素、血糖和血脂水平。采用TIMI “帧数计数” 方法诊断冠状动脉慢血流。研究了冠状动脉慢血流程度与血清胰岛素、血糖和血脂水平之间的关系。
两组的运动负荷试验结果在缺血方面均被认为是阴性的。两组患者的血清胰岛素、血糖和血脂水平无差异（p>0.05）。血清胰岛素、血糖和血脂水平与校正的TIMI帧数计数之间的相关性分析未确定相关性。
冠状动脉慢血流患者胰岛素、血糖和血脂水平正常且与cTFC缺乏相关性，这支持了冠状动脉慢血流是一种与心脏综合征X不同的临床实体的观点。
