Barradas M A, O'Donoghue S, Mikhailidis D P
Department of Chemical Pathology & Human Metabolism, Royal Free Hospital School of Medicine (University of London), United Kingdom.
In Vivo. 1992 Nov-Dec;6(6):629-34.
Platelets undergo morphological changes prior to aggregating. This phenomenon is known as the platelet shape change (PSC) and is usually accompanied by at increase in median platelet volume (MePV). We evaluated MePV changes in human platelet rich plasma (PRP) using a high resolution pulse-height analyser ("channelyzer"). Increases in MePV were induced by the addition of low concentrations of known aggregating agents. These agonists showed different patterns in terms of potency, duration and reversibility.
血小板在聚集之前会发生形态变化。这种现象被称为血小板形状改变（PSC），通常伴随着平均血小板体积（MePV）的增加。我们使用高分辨率脉冲高度分析仪（“通道分析仪”）评估了人富血小板血浆（PRP）中MePV的变化。通过添加低浓度的已知聚集剂可诱导MePV增加。这些激动剂在效力、持续时间和可逆性方面表现出不同的模式。
