Durnova G N, Burkovskaia T E, Kaplanskiĭ A S
Aviakosm Ekolog Med. 1992 Jul-Aug;26(4):57-9.
Histological, histochemical and histomorphometric methods have been used to study an effect of a 14-day head-down suspension on healing the fractured fibular diaphysis in the rats traumatized immediately after suspension. The study of the fibulae on Days 11 and 17 following an operative fracture indicated that both in control and experimental rats the ends of fractured bones were tightly interconnected by the calluses. A comparative study of the calluses and their structural components as well as detailed investigation of histological structure of calluses on the 11th and 17th post-traumatic days did not reveal significant differences between control and experimental animals. Furthermore, the rate of cartilage replacement by spongy bone tissue in calluses of experimental animals was even somewhat higher than that in control rats. Thus the data obtained give ground to believe that in a readaptation period after 14-day suspension resulting in the osteoporotic changes of weight-bearing bones a repair process in the bones is rapidly normalized and in some parameters exceeds it in control animals.
采用组织学、组织化学和组织形态计量学方法，研究了14天头低位悬吊对悬吊后立即致伤的大鼠腓骨干骨折愈合的影响。对手术骨折后第11天和第17天的腓骨进行研究表明，在对照大鼠和实验大鼠中，骨折骨的两端均被骨痂紧密连接。对创伤后第11天和第17天骨痂及其结构成分进行比较研究，并对骨痂的组织结构进行详细研究，结果显示对照动物和实验动物之间没有显著差异。此外，实验动物骨痂中软骨被松质骨组织替代的速率甚至略高于对照大鼠。因此，所获得的数据有理由让人相信，在导致负重骨骨质疏松性改变的14天悬吊后的再适应期，骨的修复过程迅速恢复正常，并且在某些参数上超过对照动物。
