亚磺酰亚胺介导的β-羟基-α-氨基膦酸酯的不对称合成。
Sulfinimine-mediated asymmetric synthesis of beta-hydroxy alpha-amino phosphonates.
作者信息
Davis Franklin A, Prasad Kavirayani R
机构信息
Department of Chemistry, Temple University, Philadelphia, Pennsylvania 19122, USA.
出版信息
J Org Chem. 2003 Sep 19;68(19):7249-53. doi: 10.1021/jo0301649.
PMID:12968873
Abstract
The addition of potassium dialkyl phosphites to enantiopure O-protected alpha-hydroxy sulfinimine pseudoenantiomers affords beta-hydroxy alpha-amino phosphonates in good yield and de. The reaction exhibits a strong match-mismatch effect.
摘要
向对映体纯的 O-保护的 α-羟基亚磺酰亚胺假对映体中加入二烷基亚磷酸钾，可高产率和高对映体过量地得到 β-羟基 α-氨基膦酸酯。该反应表现出强烈的匹配-不匹配效应。
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