因HPA - 5b不相容导致的胎儿 - 母体同种免疫性血小板减少症：一例报告

Feto-maternal alloimmune thrombocytopenia due to HPA-5b incompatibility: a case report.

作者信息

Herrero Rafael J M, Chitrit Yvon, Caubel Patrick, Lusina Daniel

机构信息

Department of Obstetrics and Gynaecology, Hôpital Robert Ballanger, Aulnay-Sous-Bois, Paris, France.

出版信息

Eur J Obstet Gynecol Reprod Biol. 2003 Oct 10;110(2):240-1. doi: 10.1016/s0301-2115(03)00108-8.

DOI:10.1016/s0301-2115(03)00108-8

PMID:12969593

Abstract

Feto-maternal alloimmune thrombocytopenia (FMAIT) results from the maternal production of antibodies against fetal platelets with incompatible antigens inherited from the father. We present a case where this condition was diagnosed prenatally without previously affected siblings. The severe fetal thrombocytopenia was due to anti-HLA-5b maternal alloantibodies. This was treated successfully by intravenous immunoglobulins. Our case reflects that FMAIT due to anti-HPA-5b may be severe and may be corrected successfully with intravenous immunoglogulins.

摘要

胎儿-母体同种免疫性血小板减少症（FMAIT）是由于母体产生针对胎儿血小板的抗体，这些血小板具有从父亲遗传的不相容抗原。我们报告一例在没有先前患病兄弟姐妹的情况下产前诊断出这种疾病的病例。严重的胎儿血小板减少症是由抗HLA-5b母体同种抗体引起的。通过静脉注射免疫球蛋白成功治疗了该疾病。我们的病例表明，由抗HPA-5b引起的FMAIT可能很严重，并且可以通过静脉注射免疫球蛋白成功纠正。