Tohtong R, Phattarasakul K, Jiraviriyakul A, Sutthiphongchai T
Department of Biochemistry, Faculty of Science, Mahidol University, Phya Thai, Bangkok, Thailand.
Prostate Cancer Prostatic Dis. 2003;6(3):212-6. doi: 10.1038/sj.pcan.4500663.
The role of myosin phosphorylation by myosin light chain kinase (MLCK) in regulating the invasiveness of metastatic cancer cells was investigated using the Dunning rat prostatic adenocarcinoma cell line, Mat Ly Lu, and in vitro invasion assay. Treatment with MLCK inhibitors resulted in marked reduction of invasiveness, which was principally due to impaired cellular motility, whereas the ability to survive and proliferate, to adhere to matrix, and to secrete gelatinases were minimally affected.
利用Dunning大鼠前列腺腺癌细胞系Mat Ly Lu和体外侵袭试验，研究了肌球蛋白轻链激酶（MLCK）介导的肌球蛋白磷酸化在调节转移性癌细胞侵袭性中的作用。用MLCK抑制剂处理导致侵袭性显著降低，这主要是由于细胞运动能力受损，而细胞存活、增殖、黏附于基质以及分泌明胶酶的能力受影响较小。
