Qi Hui-Bin, Luo Jin-Yan, Liu Xin
Department of Gastroenterology, Second Hospital of Xi'an Jiaotong University, Xi'an 710004, Shannxi Province, China.
World J Gastroenterol. 2003 Sep;9(9):2065-7. doi: 10.3748/wjg.v9.i9.2065.
To evaluate the effects of prucalopride on intestinal prokinetic activity in fast rats and to provide experimental basis for clinical treatment of gastrointestinal motility diseases.
Gastrointestinal propulsion rate was measured by the migration rate of activated charcoal, which reflexes gastrointestinal motility function. 120 Spraque-Dawley rats were randomly divided into four groups and received an intravenous injection of physiological saline (served as control), prucalopride 1 mg/kg, prucalopride 2 mg/kg and cisapride 1 mg/kg, respectively. The gastrointestinal propulsion rate was measured 1, 2 or 4 hours after intravenous injection of the drugs.
Significant accelerations of gastrointestinal propulsion rate in prucalopride 1 mg/kg and 2 mg/kg groups were found compared with control group at 2 and 4 hours(83.2 %+/-5.5 %, 81.7 %+/-8.5 % vs 70.5 %+/-9.2 %, P<0.01; 91.2 %+/-2.2 %, 91.3 %+/-3.9 % vs 86.8 %+/-2.6 %, P<0.01). The gastrointestinal propulsion rates at 1, 2 or 4 hours were faster in prucalopride 1 mg/kg and 2 mg/kg groups than in cisapride group (84.0 %+/-11.7 %, 77.1 %+/-11.9 % vs 66.3 %+/-13.6 %, P<0.01, P<0.05; 83.2 %+/-5.5 %, 81.7 %+/- 8.5 % vs 75.4 %+/-5.9 %, P<0.01, P<0.05; 91.2 %+/-2.2 %, 91.3 %+/-3.9 % vs 88.6 %+/-3.5 %,P<0.05, P<0.05). No difference of gastrointestinal propulsion rate was found between prucalopride 1 mg/kg group and prucalopride 2 mg/kg group (P>0.05).
Prucalopride accelerates intestinal motility in fast rats, and has no dose dependent effect.
评价普芦卡必利对禁食大鼠肠道促动力活性的影响，为临床治疗胃肠动力性疾病提供实验依据。
采用活性炭移动率测定胃肠推进率，以反映胃肠动力功能。将120只Spraque-Dawley大鼠随机分为四组，分别静脉注射生理盐水（作为对照组）、1 mg/kg普芦卡必利、2 mg/kg普芦卡必利和1 mg/kg西沙必利。在静脉注射药物后1、2或4小时测量胃肠推进率。
与对照组相比，1 mg/kg和2 mg/kg普芦卡必利组在2小时和4小时时胃肠推进率显著加快（83.2%±5.5%，81.7%±8.5%对70.5%±9.2%，P<0.01；91.2%±2.2%，91.3%±3.9%对86.8%±2.6%，P<0.01）。1 mg/kg和2 mg/kg普芦卡必利组在1、2或4小时时的胃肠推进率比西沙必利组更快（84.0%±11.7%，77.1%±11.9%对66.3%±13.6%，P<0.01，P<0.05；83.2%±5.5%，81.7%±8.5%对75.4%±5.9%，P<0.01，P<0.05；91.2%±2.2%，91.3%±3.9%对88.6%±3.5%，P<0.05，P<0.05）。1 mg/kg普芦卡必利组和2 mg/kg普芦卡必利组之间的胃肠推进率无差异（P>0.05）。
普芦卡必利可加快禁食大鼠的肠道蠕动，且无剂量依赖性效应。
