[Improved method of epalrestat synthesis].
作者信息
Sheng Rong, Liu Tao, Hu Yong-zhou
机构信息
Institute of Pharmaceutic Research, College of Pharmaceutical Sciences, Zhejiang University, Hangzhou 310031, China.
出版信息
Zhejiang Da Xue Xue Bao Yi Xue Ban. 2003 Aug;32(4):356-8. doi: 10.3785/j.issn.1008-9292.2003.04.022.
OBJECTIVE
To synthesize epalrestat and to improve the method of synthesis.
METHODS
Glycine reacted with carbondisulfide,then with ClCH(2)COONa to give 3-carboxymethylrhodanine. PhCHO reacted with CH(3)CH(2)CHO in NaOH/EtOH solution to produce 2-methylcinnamaldehyde.3-carboxymethylrhodanine and 2-methylcinnamaldehyde were treated with NH(3).H(2)O to obtain epalrestat.
RESULT
The described method was effective in synthesis of Epalrestat and the yield was higher than that of in references.
CONCLUSION
The results suggest that this method is suitable for industrial production.
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