Tu Chao, Lin Jun, Shao Ying, Guo Zijian
State Key Laboratory of Coordination Chemistry, Coordination Chemistry Institute, Nanjing University, 210093 Nanjing, P. R. China.
Inorg Chem. 2003 Sep 22;42(19):5795-7. doi: 10.1021/ic034604q.
A novel hexadentate ligand, N,N,N',N',N",N"-hexa(2-pyridyl)-1,3,5-tris(aminomethyl)benzene (L), was designed and synthesized. The X-ray structure analysis reveals that the three dipyridylamine (DPA) groups of L are almost perpendicular to the central trimethylenebenzene, and two of them are spacially close to each other while the third one is further apart. The trinuclear Pt(II) complexes [Pt(3)LCl(6)] (1) and [Pt(3)L(CBDCA)(3)] (2) (where CBDCA represents cyclobutane dicarboxylic acid) were prepared and fully characterized by IR, NMR, and ESMS spectroscopy. A mononuclear complex, [PtL(CBDCA)] (3), was also prepared and structurally characterized, which suggests that controlled formation of mono-, di-, and trinuclear complexes with L is possible. Spectroscopic data showed that complexes 2 and 3 are able to bind to calf thymus DNA and their CBDCA group can be readily replaced by thiourea.
设计并合成了一种新型六齿配体N,N,N',N',N",N"-六(2-吡啶基)-1,3,5-三(氨甲基)苯(L)。X射线结构分析表明，L的三个二吡啶胺(DPA)基团几乎垂直于中心三亚甲基苯，其中两个在空间上彼此靠近，而第三个则相距较远。制备了三核铂(II)配合物Pt(3)LCl(6)和Pt(3)L(CBDCA)(3)(其中CBDCA代表环丁烷二羧酸)，并通过红外光谱、核磁共振光谱和电喷雾质谱对其进行了全面表征。还制备了单核配合物PtL(CBDCA)并对其结构进行了表征，这表明与L可控形成单核、双核和三核配合物是可能的。光谱数据表明，配合物2和3能够与小牛胸腺DNA结合，并且它们的CBDCA基团可以很容易地被硫脲取代。
