Kulke Matthew H
Dana-Farber Cancer Institute and Harvard Medical School, Department of Medical Oncology, Boston, MA 0215, USA.
Cancer Treat Rev. 2003 Oct;29(5):363-70. doi: 10.1016/s0305-7372(03)00072-0.
Neuroendocrine tumours often present a diagnostic and therapeutic challenge. They can arise almost anywhere in the body, and are therefore associated with a broad range of local symptoms. The systemic manifestations of neuroendocrine tumours are also diverse, and are related to the secretion of numerous hormones and biogenic amines. In recent years, improved diagnostic techniques, increased recognition of neuroendocrine tumour subtypes, and new therapeutic modalities have enhanced clinicians' ability to detect and appropriately treat these malignancies.
神经内分泌肿瘤常常带来诊断和治疗方面的挑战。它们几乎可在身体的任何部位出现，因此会伴有各种各样的局部症状。神经内分泌肿瘤的全身表现也多种多样，且与多种激素和生物胺的分泌有关。近年来，诊断技术的改进、对神经内分泌肿瘤亚型认识的增加以及新的治疗方式提高了临床医生检测和恰当治疗这些恶性肿瘤的能力。
