小鼠曲霉病的联合抗真菌治疗：脂质体两性霉素B和米卡芬净。
Combination antifungal therapy of murine aspergillosis: liposomal amphotericin B and micafungin.
作者信息
Graybill John R, Bocanegra Rosie, Gonzalez Gloria M, Najvar Laura K
机构信息
The University of Texas Health Science Center at San Antonio, Department of Medicine, Division of Infectious Diseases (7881), 7703 Floyd Curl Drive, San Antonio, TX 78229-3900, USA.
出版信息
J Antimicrob Chemother. 2003 Oct;52(4):656-62. doi: 10.1093/jac/dkg425. Epub 2003 Sep 12.
OBJECTIVES
AmBisome and micafungin were used alone and in combination in a series of studies designed to identify any additive or antagonistic effects of combination antifungal therapy.
METHODS
Immune-suppressed mice were infected either intravenously or intranasally with Aspergillus fumigatus. Micafungin, liposomal amphotericin B or both drugs together were administered for 7 days. Parameters of efficacy included survival and tissue burden of A. fumigatus.
RESULTS
Whilst each drug was effective in murine aspergillosis, additive effects were observed only in reduction of tissue burden in limited experimental conditions. No antagonism was seen.
CONCLUSIONS
The present studies neither encourage nor discourage clinical use of combination therapy. Clinical trials are suggested before combined therapy is routinely adopted.
目的
在一系列旨在确定联合抗真菌治疗的任何相加或拮抗作用的研究中，单独及联合使用了安必素和米卡芬净。
方法
免疫抑制小鼠通过静脉内或鼻内感染烟曲霉。给予米卡芬净、脂质体两性霉素B或两种药物联合使用7天。疗效参数包括烟曲霉的存活率和组织负荷。
结果
虽然每种药物对小鼠曲霉病均有效，但仅在有限的实验条件下观察到在减轻组织负荷方面有相加作用。未观察到拮抗作用。
结论
本研究既不鼓励也不反对联合治疗的临床应用。建议在常规采用联合治疗之前进行临床试验。
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