Miner Jeffrey H
Renal Division and Department of Cell Biology and Physiology, Washington University School of Medicine, St. Louis, Mo 63110, USA.
Nephron Exp Nephrol. 2003;94(4):e119-22. doi: 10.1159/000072495.
The glomerular barrier is the kidney's physical block to the unrestricted flow of molecules from the plasma into the urinary space. Its exquisite selectivity allows solutes and water in the glomerular capillaries to pass through, but it prevents the bulk of plasma proteins, most notably albumin, from crossing. Classically, the barrier consists of three distinct components: glomerular endothelium, glomerular basement membrane, and glomerular epithelium (podocytes). In this review, I discuss these three components, with particular emphasis on the barrier presumed to be imparted by a specialized podocyte cell-cell junction, the glomerular slit diaphragm.
肾小球屏障是肾脏阻止分子从血浆无限制地流入尿液空间的物理屏障。其高度的选择性允许肾小球毛细血管中的溶质和水通过，但阻止大多数血浆蛋白，尤其是白蛋白通过。传统上，该屏障由三个不同的成分组成：肾小球内皮、肾小球基底膜和肾小球上皮（足细胞）。在这篇综述中，我将讨论这三个成分，特别强调被认为由一种特殊的足细胞间细胞连接——肾小球裂孔隔膜所赋予的屏障作用。
