Hammoud Majeda S, Elsori Hassan A, Hanafi Emad-Aldeen M, Shalabi Adel A, Fouda Ibrahim A, Devarajan Lakshmi V
Department of Pediatrics, Faculty of Medicine, Kuwait University, PO Box 24923, Safat, Code # 13110, Kuwait.
Saudi Med J. 2003 Sep;24(9):982-5.
Patent ductus arteriosus (PDA) is considered to be an important cause of morbidity and mortality among preterm infants. The aim of this study is to determine the incidence of PDA in ventilated preterm infants with respiratory distress syndrome (RDS) and to evaluate the role of some antenatal risk factors on its occurrence in our population.
The case records of the preterm infants of <34 weeks gestational age, who were ventilated for RDS at the neonatal intensive care unit of Maternity Hospital, Safat, Kuwait, between March 1998 and February 1999, were reviewed. Diagnosis of PDA was based on echocardiographic findings. The association between the risk factors chosen and the PDA was also evaluated.
A total of 101 infants whose gestational ages ranged between 25-33 weeks, and birth weights between 685-1580 grams were included. Fifty-four had a significant PDA (53.4%). Maternal diabetes and antepartum hemorrhage (APH), birth weights, gestational ages, multiplicity and gender of the infants were found to be related to the incidence of PDA.
The incidence of PDA in our ventilated preterm infants with RDS is similar to those reported from other neonatal units outside Kuwait. There are some factors that may identify babies, who are prone to develop PDA, which need to be confirmed by further prospective studies using a larger population.
动脉导管未闭（PDA）被认为是早产儿发病和死亡的重要原因。本研究的目的是确定患有呼吸窘迫综合征（RDS）的机械通气早产儿中PDA的发生率，并评估一些产前危险因素在我们人群中其发生的作用。
回顾了1998年3月至1999年2月在科威特萨法特妇产医院新生儿重症监护病房因RDS接受机械通气的孕周小于34周的早产儿的病例记录。PDA的诊断基于超声心动图检查结果。还评估了所选危险因素与PDA之间的关联。
共纳入101例孕周在25 - 33周之间、出生体重在685 - 1580克之间的婴儿。54例有显著的PDA（53.4%）。发现母亲糖尿病和产前出血（APH）、婴儿的出生体重、孕周、多胎情况和性别与PDA的发生率有关。
我们患有RDS的机械通气早产儿中PDA的发生率与科威特以外其他新生儿病房报告的发生率相似。有一些因素可能识别出易患PDA的婴儿，这需要通过使用更大样本量的进一步前瞻性研究来证实。
